from /pol/… Liu predicted this: Enhancing antibodies Anonymous (ID: bB3DGQBg) 11/26/21 (Fri) 18:18:38 No.349608560 https://boards.4chan.org/pol/thread/349608560
SARS-CoV-2 Delta variant is poised to acquire complete resistance to wild-type spike vaccines
File: Lui 2021 mutations at RBD.png (139 KB, 1697×949)
The paper titled ‘The SARS-CoV-2 Delta variant is poised to acquire complete resistance to wild-type spike vaccines’ showed how the Pfizer vaccine (and presumably all the other vaccines) could result in a variant that took advantage of the enhancing antibodies that target the NTD of the S1 subunit of the spike protein by mutations in the RBD.
> https://www.biorxiv.org/content/10.
I made a video a couple of months ago to explain it:
>>>>>/wsg/4232832 [see below]
This is the list of mutations in the RBD of the new omicron variant:
K417N, N440K, G446S, S477N, T478K, E484A, Q493K, G496S, Q498R, N501Y, Y505H
The four mutations that this research group tested and found antibody enhancement were:
K417N – found in omicron
N439K – mutation is one amino acid over at 440
E484K – instead of lysine (K) it was mutated to alanine (A)
N501Y – found in omicron
The other mutations also probably help evade antibodies targeting the RBD section of the vaccine. It is not clear yet if enhancing antibodies are causing the enormous infectivity, we will probably need to compare people that were vaccinated in the past few months with those that were unvaccinated.